IoPlex with I-PlexomerTM is the world’s only controlled release iodine foam dressing. A proprietary controlled-release system allows for regulated and sustained infection management through the slow release of iodine within the wound dressing. More than 90% of chronic wounds contain biofilm, which stalls wound healing and contributes to chronicity. Biofilm is very difficult to remove because it firmly adheres to surrounding tissue and it is highly tolerant to antibiotics. Not even debridement adequately manages biofilm. Long known as a powerful antiseptic, numerous in-vitro studies demonstrate its superiority to other antibacterial agents–including silver–at controlling biofilm. Iodine has been used in wound care since the American Civil War. Although quite cytotoxic in its native state, the iodine of today is bonded to a carrier molecule for a gentler release that maintains efficacy against microorganisms.